Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.

Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP
FEBS J. 2006 273 (10): 2223-31

PMID: 16649998 · DOI:10.1111/j.1742-4658.2006.05235.x

MeSH Terms (14)

7-Alkoxycoumarin O-Dealkylase Animals Binding, Competitive Catalysis Cytochrome P-450 CYP1A2 Cytochrome P-450 Enzyme System Deuterium Humans Isotope Labeling Kinetics Microsomes, Liver Molecular Structure Oxidation-Reduction Rats

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