Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus.

Stanic AK, Stein CM, Morgan AC, Fazio S, Linton MF, Wakeland EK, Olsen NJ, Major AS
Proc Natl Acad Sci U S A. 2006 103 (18): 7018-23

PMID: 16636270 · PMCID: PMC1459011 · DOI:10.1073/pnas.0602311103

Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. The underlying mechanisms are poorly understood, and investigations have been hampered by the absence of animal models that reflect the human condition of generalized atherosclerosis and lupus. We addressed this problem by transferring lupus susceptibility to low-density lipoprotein (LDL) receptor-deficient (LDLr-/-) mice, an established model of atherosclerosis, creating radiation chimeras with NZM2410-derived, lupus-susceptible, B6.Sle1.2.3 congenic or C57BL/6 control donors (LDLr.Sle and LDLr.B6, respectively). LDLr.Sle mice developed a lupus-like disease characterized by production of double-stranded DNA autoantibodies and renal disease. When fed a Western-type diet, LDLr.Sle chimeras had increased mortality and atherosclerotic lesions. The plaques of LDLr.Sle mice were highly inflammatory and contained more CD3+ T cells than controls. LDLr.Sle mice also had increased activation of CD4+ T and B cells and significantly higher antibody to oxidized LDL and cardiolipin. Collectively, these studies demonstrate that the lupus-susceptible immune system enhances atherogenesis and modulates plaque composition.

MeSH Terms (16)

Animals Antibodies, Antiphospholipid Atherosclerosis Bone Marrow Transplantation Diet Humans Immune System Lupus Erythematosus, Systemic Mice Mice, Inbred C57BL Mice, Knockout Phenotype Radiation Chimera Receptors, LDL Spleen Thymus Gland

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