Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain.

Haase VH, Snijders AJ, Cooke SM, Teng MN, Kaul D, Le Beau MM, Bruns GA, Bernards A
Oncogene. 1991 6 (12): 2319-25

PMID: 1662793

Ltk is a new member of the ros/insulin receptor family of tyrosine kinases that is expressed in murine B-lymphocyte precursors and forebrain neurons. We previously reported that lymphoid ltk cDNAs predict a 69 kDa transmembrane glycoprotein, which uses a CUG translational start codon and has a 110 amino acid putative extracellular domain. We now show that the predominant ltk mRNA in brain is alternatively spliced and predicts a protein with a substantially larger extracellular part. The human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas.

MeSH Terms (25)

Amino Acid Sequence Animals B-Lymphocytes Base Sequence Brain Cells, Cultured Chromosome Banding Chromosomes, Human, Pair 15 Cloning, Molecular Codon DNA Exons Genomic Library Humans Lymphocytes Membrane Glycoproteins Mice Molecular Sequence Data Neurons Protein-Tyrosine Kinases Receptor, Insulin Restriction Mapping RNA, Messenger RNA Splicing Sequence Homology, Nucleic Acid

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