Correlates of syphilis seroreactivity among pregnant women: the HIVNET 024 Trial in Malawi, Tanzania, and Zambia.

Potter D, Goldenberg RL, Read JS, Wang J, Hoffman IF, Saathoff E, Kafulafula G, Aboud S, Martinson FE, Dahab M, Vermund SH
Sex Transm Dis. 2006 33 (10): 604-9

PMID: 16601659 · PMCID: PMC2743105 · DOI:10.1097/

OBJECTIVES - The objectives of this cross-sectional study were to determine correlates of syphilis seroprevalence among HIV-infected and -uninfected antenatal attendees in an African multisite clinical trial, and to improve strategies for maternal syphilis prevention.

RESULTS - A total of 2,270 (86%) women were HIV-infected and 366 (14%) were HIV-uninfected. One hundred seventy-five (6.6%) were syphilis-seropositive (7.3% among HIV-infected and 2.6% HIV-uninfected women). Statistically significant correlates included geographic site (odds ratio [OR] = 4.5, Blantyre; OR = 3.2, Lilongwe; OR = 9.0, Lusaka vs. Dar es Salaam referent); HIV infection (OR = 3.3); age 20 to 24 years (OR = 2.5); being divorced, widowed, or separated (OR = 2.9); genital ulcer treatment in the last year (OR = 2.9); history of stillbirth (OR = 2.8, one stillbirth; OR = 4.3, 2-5 stillbirths); and history of preterm delivery (OR = 2.7, one preterm delivery).

CONCLUSION - Many women without identified risk factors were syphilis-seropositive. Younger HIV-infected women were at highest risk. Universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings.

MeSH Terms (17)

Adolescent Adult Africa South of the Sahara Age Factors Clinical Trials as Topic Comorbidity Cross-Sectional Studies Female HIV Infections Humans Middle Aged Pregnancy Pregnancy Complications, Infectious Risk Factors Seroepidemiologic Studies Syphilis Syphilis Serodiagnosis

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