Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States).

Peterson NB, Trentham-Dietz A, Newcomb PA, Chen Z, Gebretsadik T, Hampton JM, Stampfer MJ, Willett WC, Egan KM
Cancer Causes Control. 2006 17 (4): 459-67

PMID: 16596298 · DOI:10.1007/s10552-005-0416-1

OBJECTIVE - To examine the relationship between anthropometric measures and ovarian cancer by menopausal status.

METHODS - We analyzed data from a population-based case-control study comprised of 700 incident cases of epithelial ovarian cancer and 5,943 population controls from Massachusetts and Wisconsin enrolled between 1993 and 2001. In a telephone interview, information was gathered on established ovarian cancer risk factors, as well as adult height and age-specific body weight. Logistic regression was used to estimate multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for body mass index (BMI) throughout life.

RESULTS - Recent BMI had no significant association with ovarian cancer risk (P-trend 0.14 for continuous BMI), after adjustment for age and other ovarian cancer risk factors. However, a non-significant positive association (overall P-trend 0.08) was observed for BMI at age 20; the risk estimate comparing a body mass of >25 kg/m2 to the lowest quintile (
CONCLUSION - Results of this study suggest that maintenance of a lean body mass, particularly in early adult life, may decrease ovarian cancer risk.

MeSH Terms (16)

Adult Aged Aged, 80 and over Body Height Body Mass Index Body Weight Case-Control Studies Female Humans Massachusetts Menopause Middle Aged Odds Ratio Ovarian Neoplasms Risk Factors Wisconsin

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