Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.

Vilgelm A, Lian Z, Wang H, Beauparlant SL, Klein-Szanto A, Ellenson LH, Di Cristofano A
Cancer Res. 2006 66 (7): 3375-80

PMID: 16585156 · DOI:10.1158/0008-5472.CAN-05-4019

MeSH Terms (11)

Animals Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometrial Neoplasms Estrogen Receptor alpha Female Mice Mice, Inbred C57BL Phosphorylation Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase

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