Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH
Science. 2006 311 (5768): 1774-5

PMID: 16556844 · DOI:10.1126/science.1123510

Autoimmune destruction of beta cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although beta cells in these mice were not derived from donor splenocytes.

MeSH Terms (19)

Animals Autoimmunity Blood Glucose Cell Differentiation Cell Transplantation Combined Modality Therapy Diabetes Mellitus, Type 1 Female Freund's Adjuvant Green Fluorescent Proteins Insulin-Secreting Cells Islets of Langerhans Transplantation Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Regeneration Spleen Stem Cells

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