Factor XI activation in a revised model of blood coagulation.

Gailani D, Broze GJ
Science. 1991 253 (5022): 909-12

PMID: 1652157 · DOI:10.1126/science.1652157

Coagulation factor XI is activated in vitro by factor XIIa in the presence of high molecular weight kininogen (HMWK) and a negatively charged surface. Factor XII deficiency is not associated with bleeding, which suggests that another mechanism for factor XI activation exists in vivo. A revised model of coagulation is proposed in which factor XI is activated by thrombin. In the absence of cofactors, thrombin is more effective (kcat/Km = 1.6 x 10(5)) than factor XIIa (1.7 x 10(4)) in activating factor XI. Dextran sulfate enhances activation of factor XI by thrombin 2000-fold; part of this effect is due to autoactivation of factor XI by activated factor XI.

MeSH Terms (15)

Blood Coagulation Chromogenic Compounds Dextran Sulfate Factor XI Factor XIIa Hemostasis Kininogens Macromolecular Substances Models, Biological Oligopeptides Pyrrolidonecarboxylic Acid Receptors, Cell Surface Receptors, Thrombin Recombinant Proteins Thrombin

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