The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.

McClendon AK, Osheroff N
Biochemistry. 2006 45 (9): 3040-50

PMID: 16503659 · PMCID: PMC2517258 · DOI:10.1021/bi051987q

MeSH Terms (13)

Antigens, Neoplasm Antineoplastic Agents DNA, Superhelical DNA-Binding Proteins DNA Topoisomerases, Type II Dose-Response Relationship, Drug Etoposide Humans Intercalating Agents Plasmids Recombinant Proteins Saccharomyces cerevisiae Time Factors

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