Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.

Cho YJ, Wang H, Kozekov ID, Kurtz AJ, Jacob J, Voehler M, Smith J, Harris TM, Lloyd RS, Rizzo CJ, Stone MP
Chem Res Toxicol. 2006 19 (2): 195-208

PMID: 16485895 · PMCID: PMC2631444 · DOI:10.1021/tx050239z

MeSH Terms (23)

Acetaldehyde Aldehydes Animals Carbon Isotopes Chlorocebus aethiops COS Cells CpG Islands Cross-Linking Reagents Deoxyguanosine DNA DNA Adducts Hydrogen-Ion Concentration Hydrogen Bonding Isotope Labeling Methanol Models, Molecular Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oligodeoxyribonucleotides Stereoisomerism Substrate Specificity Temperature Time Factors

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