Heat shock proteins in cancer: chaperones of tumorigenesis.

Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR
Trends Biochem Sci. 2006 31 (3): 164-72

PMID: 16483782 · DOI:10.1016/j.tibs.2006.01.006

The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide range of tumors and are closely associated with a poor prognosis and resistance to therapy. The increased transcription of HSPs in tumor cells is due to loss of p53 function and to higher expression of the proto-oncogenes HER2 and c-Myc, and is crucial to tumorigenesis. The HSP family members play overlapping, essential roles in tumor growth both by promoting autonomous cell proliferation and by inhibiting death pathways. The HSPs have thus become targets for rational anti-cancer drug design: HSP90 inhibitors are currently showing much promise in clinical trials, whereas the increased expression of HSPs in tumors is forming the basis of chaperone-based immunotherapy.

MeSH Terms (8)

Animals Cell Transformation, Neoplastic Disease Progression Heat-Shock Proteins Humans Molecular Chaperones Neoplasms Phenotype

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