Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.

Wendt MD, Shen W, Kunzer A, McClellan WJ, Bruncko M, Oost TK, Ding H, Joseph MK, Zhang H, Nimmer PM, Ng SC, Shoemaker AR, Petros AM, Oleksijew A, Marsh K, Bauch J, Oltersdorf T, Belli BA, Martineau D, Fesik SW, Rosenberg SH, Elmore SW
J Med Chem. 2006 49 (3): 1165-81

PMID: 16451081 · DOI:10.1021/jm050754u

MeSH Terms (23)

Aniline Compounds Animals Antineoplastic Agents bcl-X Protein Biological Availability Cell Line, Tumor Drug Screening Assays, Antitumor Drug Synergism Fluorescence Polarization Humans Magnetic Resonance Spectroscopy Mice Mice, SCID Paclitaxel Piperidines Protein Binding Protein Structure, Tertiary Serum Serum Albumin Stereoisomerism Sulfonamides Transplantation, Heterologous Ultraviolet Rays

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