Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.

Petros AM, Dinges J, Augeri DJ, Baumeister SA, Betebenner DA, Bures MG, Elmore SW, Hajduk PJ, Joseph MK, Landis SK, Nettesheim DG, Rosenberg SH, Shen W, Thomas S, Wang X, Zanze I, Zhang H, Fesik SW
J Med Chem. 2006 49 (2): 656-63

PMID: 16420051 · DOI:10.1021/jm0507532

MeSH Terms (11)

Aniline Compounds bcl-X Protein Binding Sites Hydrophobic and Hydrophilic Interactions Ligands Magnetic Resonance Spectroscopy Models, Molecular Protein Binding Solubility Structure-Activity Relationship Sulfonamides

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