Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease.

Gunstad J, Cohen RA, Tate DF, Paul RH, Poppas A, Hoth K, Macgregor KL, Jefferson AL
Blood Press. 2005 14 (6): 353-8

PMID: 16403689 · PMCID: PMC3215278 · DOI:10.1080/08037050500364117

The present study examined the relationship between multiple blood pressure (BP) indices and white matter hyperintensities (WMH) in a sample of 39 older adults with cardiovascular disease (CVD). Resting BP was measured using an automated monitor every 10 min for 2 h. WMH were quantified on FLAIR images and separate indices were generated for neocortical, periventricular and subcortical brain regions. Correlation analyses revealed systolic BP variability was related to neocortical and total WMH. A function of systolic BP variability and average diastolic pressure showed the strongest relationships, including significant correlation to neocortical, subcortical and total WMH. No BP index was related to WMH in periventricular regions. Exploratory analyses showed only the function of systolic BP variability and average diastolic pressure predicted total WMH, whereas as age, CVD conditions and psychosocial factors did not. These findings demonstrate BP variability is an important contributor to WMH in older adults with CVD and suggests it may have differential relationships to WMH in different brain regions. Additional studies are needed to examine the role of autoregulatory systems in the development of WMH, particularly those using beat-to-beat measures of BP.

MeSH Terms (13)

Aged Aged, 80 and over Blood Pressure Brain Cardiovascular Diseases Cerebrovascular Disorders Female Humans Hypertension Magnetic Resonance Imaging Male Middle Aged Statistics as Topic

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