Growth factor receptors: implications in tumor biology.

Srinivasan DM, Kapoor M, Kojima F, Crofford LJ
Curr Opin Investig Drugs. 2005 6 (12): 1246-9

PMID: 16370390

Growth factors are signaling molecules which bind to cell surface receptors and mediate a myriad of intracellular functions. Growth factor signaling is vital for growth and differentiation of cells under normal physiological conditions. However, aberrant signaling of these molecules via their receptors enables the cells to acquire abnormal characteristics most commonly observed in tumor cells. Tumor biology studies have revealed a central role for growth factor receptors in tumor progression. This review discusses the involvement of growth factor receptors in solid tumor formation and their value as potential anticancer drug targets.

MeSH Terms (11)

Animals Anti-Inflammatory Agents, Non-Steroidal Antineoplastic Agents ErbB Receptors Humans Mutation Neoplasms Receptor Protein-Tyrosine Kinases Receptors, Growth Factor Receptors, Platelet-Derived Growth Factor Signal Transduction

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