Under pressure: stromal fibroblasts change their ways.

Bierie B, Moses HL
Cell. 2005 123 (6): 985-7

PMID: 16360028 · DOI:10.1016/j.cell.2005.11.029

In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.

MeSH Terms (13)

Animals Connective Tissue Disease Models, Animal Epithelial Cells Fibroblasts Male Mice Models, Biological Mutation Paracrine Communication Prostatic Neoplasms Stromal Cells Tumor Suppressor Protein p53

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