SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.

Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H
J Biol Chem. 2006 281 (6): 3198-203

PMID: 16339146 · PMCID: PMC8010168 · DOI:10.1074/jbc.M508381200

MeSH Terms (20)

Angiotensin-Converting Enzyme 2 Animals Carboxypeptidases Cathepsin L Cathepsins Cell Line Chlorocebus aethiops Coronavirus Cysteine Endopeptidases Endosomes Green Fluorescent Proteins Humans Lysosomes Membrane Glycoproteins Peptidyl-Dipeptidase A Retroviridae SARS Virus Species Specificity Vero Cells Viral Envelope Proteins

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