Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica.

Kabagambe EK, Baylin A, Ruiz-Narvaez E, Rimm EB, Campos H
Am J Clin Nutr. 2005 82 (6): 1336-45

PMID: 16332668 · DOI:10.1093/ajcn/82.6.1336

BACKGROUND - Moderate alcohol consumption is associated with a lower risk of myocardial infarction (MI). Whether alcohol is truly protective or whether the amount, type, or pattern of intake is the most important is still under debate.

OBJECTIVE - The purpose of this study was to determine whether alcohol intake and drinking patterns are associated with plasma lipids and the risk of MI in Costa Ricans, a population with a low intake of wine.

DESIGN - We conducted a study of 2090 cases of a first nonfatal acute MI and 2090 population-based controls matched by age, sex, and residence in Costa Rica, a country with diet and lifestyles different from those of Western countries. Alcohol and dietary intakes were assessed by using validated questionnaires.

RESULTS - In a multivariate conditional regression model that controlled for other cardiovascular disease risk factors, the lowest risk of MI [odds ratio (OR) = 0.44; 95% CI: 0.31, 0.61] was observed for those who drank on average 3 drinks/wk (compared with lifelong abstainers). When we looked at the frequency of consumption, we found that the risk of MI among daily drinkers (OR = 0.64; 95% CI: 0.41, 1.01) was not significantly different (P = 0.23) from that of weekend drinkers (OR = 0.76; 95% CI: 0.59, 0.98) regardless of the amount consumed. HDL cholesterol increased with the amount and frequency of alcohol intake. Similar to a few other populations, apparent protection was observed at very low alcohol intakes.

CONCLUSION - Low to moderate consumption of alcohol 1-2 d/wk is independently associated with a reduced risk of MI.

MeSH Terms (19)

Acute Disease Alcohol Drinking Case-Control Studies Cholesterol, HDL Confidence Intervals Costa Rica Diet Dose-Response Relationship, Drug Female Humans Life Style Male Middle Aged Multivariate Analysis Myocardial Infarction Odds Ratio Risk Factors Surveys and Questionnaires Temperance

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