Sex-related differences in amygdala functional connectivity during resting conditions.

Kilpatrick LA, Zald DH, Pardo JV, Cahill LF
Neuroimage. 2006 30 (2): 452-61

PMID: 16326115 · DOI:10.1016/j.neuroimage.2005.09.065

Recent neuroimaging studies have established a sex-related hemispheric lateralization of amygdala involvement in memory for emotionally arousing material. Here, we examine the possibility that sex-related differences in amygdala involvement in memory for emotional material develop from differential patterns of amygdala functional connectivity evident in the resting brain. Seed voxel partial least square analyses of regional cerebral blood flow data revealed significant sex-related differences in amygdala functional connectivity during resting conditions. The right amygdala was associated with greater functional connectivity in men than in women. In contrast, the left amygdala was associated with greater functional connectivity in women than in men. Furthermore, the regions displaying stronger functional connectivity with the right amygdala in males (sensorimotor cortex, striatum, pulvinar) differed from those displaying stronger functional connectivity with the left amygdala in females (subgenual cortex, hypothalamus). These differences in functional connectivity at rest may link to sex-related differences in medical and psychiatric disorders.

MeSH Terms (16)

Adult Amygdala Brain Cerebrovascular Circulation Data Interpretation, Statistical Emotions Female Functional Laterality Humans Image Processing, Computer-Assisted Least-Squares Analysis Male Nerve Net Neural Pathways Positron-Emission Tomography Sex Characteristics

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