Spatial working memory deficits in adolescents at clinical high risk for schizophrenia.

Smith CW, Park S, Cornblatt B
Schizophr Res. 2006 81 (2-3): 211-5

PMID: 16321508 · DOI:10.1016/j.schres.2005.09.019

Identifying endophenotypic markers is crucial to schizophrenia research for finding appropriate preventive strategies. Working memory (WM) deficit has been suggested as a marker for schizophrenia but its presence in adolescents at high risk is understudied. We piloted a test of spatial WM function in adolescents at clinical high risk (CHR) for schizophrenia and in age- and IQ-matched low-risk control subjects. CHR adolescents showed deficits in spatial WM compared with controls but showed intact performance on a non-WM-demanding spatial control task. Although based on a small pilot study, the results strongly suggest that WM deficit may be a risk factor for psychosis.

MeSH Terms (17)

Adolescent Attention Female Humans Male Memory, Short-Term Orientation Pattern Recognition, Visual Phenotype Pilot Projects Psychomotor Performance Reaction Time Retention, Psychology Risk Schizophrenia Schizophrenic Psychology Schizotypal Personality Disorder

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