Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis.

Ellacott KL, Halatchev IG, Cone RD
Peptides. 2006 27 (2): 340-9

PMID: 16309792 · DOI:10.1016/j.peptides.2005.02.031

Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY(3-36).

MeSH Terms (12)

Animals Cholecystokinin Energy Metabolism Gastrointestinal Tract Ghrelin Homeostasis Humans Melanocyte-Stimulating Hormones Peptide Fragments Peptide Hormones Peptides Peptide YY

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