Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase.

Chandu D, Huppert SS, Kopan R
J Neurochem. 2006 96 (1): 228-35

PMID: 16300632 · DOI:10.1111/j.1471-4159.2005.03547.x

MeSH Terms (16)

Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Cell Line Cell Membrane Cytosol Endopeptidases Humans Hydrolysis Immunoprecipitation Isoenzymes Leucine Methionine Mutation Peptide Hydrolases Protease Inhibitors Receptor, Notch1

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