The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development.

Desmots F, Russell HR, Lee Y, Boyd K, McKinnon PJ
Mol Cell Biol. 2005 25 (23): 10329-37

PMID: 16287848 · PMCID: PMC1291232 · DOI:10.1128/MCB.25.23.10329-10337.2005

Scythe (BAT3 [HLA-B-associated transcript 3]) is a nuclear protein that has been implicated in apoptosis, as it can modulate Reaper, a central apoptotic regulator in Drosophila melanogaster. While Scythe can markedly affect Reaper-dependent apoptosis in Xenopus laevis cell extracts, the function of Scythe in mammals is unknown. Here, we report that inactivation of Scythe in the mouse results in lethality associated with pronounced developmental defects in the lung, kidney, and brain. In all cases, these developmental defects were associated with dysregulation of apoptosis and cellular proliferation. Scythe-/- cells were also more resistant to apoptosis induced by menadione and thapsigargin. These data show that Scythe is critical for viability and normal development, probably via regulation of programmed cell death and cellular proliferation.

MeSH Terms (16)

Animals Apoptosis Brain Carrier Proteins Cell Proliferation Embryo, Mammalian Embryo Loss Embryonic Development Gene Expression Regulation, Developmental Kidney Lung Mice Mice, Knockout Molecular Chaperones Nuclear Proteins Protein Binding

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