Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.

Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M
Hum Mol Genet. 2005 14 (24): 3857-64

PMID: 16278235 · DOI:10.1093/hmg/ddi410

MeSH Terms (17)

Animals Apoptosis Cell Proliferation Hepatocytes Iron-Binding Proteins Iron-Sulfur Proteins Liver Liver Neoplasms Longevity Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Oxidative Stress p38 Mitogen-Activated Protein Kinases Phosphorylation Reactive Oxygen Species

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