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Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots.

Tomlinson ID, Mason JN, Blakely RD, Rosenthal SJ
Bioorg Med Chem Lett. 2005 15 (23): 5307-10

PMID: 16183285 · DOI:10.1016/j.bmcl.2005.08.030

There is a growing demand for compounds with specificity for the serotonin transporter protein (SERT) that can be conjugated to cadmium selenide/zinc sulfide core shell nanocrystals. This letter describes the design and synthesis of two different biotinylated SERT antagonists that can be attached to streptavidin-coated cadmium selenide/zinc sulfide core shell nanocrystals.

MeSH Terms (9)

Biotinylation Humans Imidazoles Indoles Ligands Molecular Structure Quantum Dots Serotonin Plasma Membrane Transport Proteins Serotonin Uptake Inhibitors

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