Effect of ductus ligation on cardiopulmonary function in premature baboons.

McCurnin DC, Yoder BA, Coalson J, Grubb P, Kerecman J, Kupferschmid J, Breuer C, Siler-Khodr T, Shaul PW, Clyman R
Am J Respir Crit Care Med. 2005 172 (12): 1569-74

PMID: 16179644 · PMCID: PMC2718457 · DOI:10.1164/rccm.200502-230OC

RATIONALE - The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear.

OBJECTIVE - To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates.

METHODS - Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14.

RESULTS - Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology.

CONCLUSION - Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.

MeSH Terms (17)

Animals Animals, Newborn Cardiovascular System Disease Models, Animal Ductus Arteriosus, Patent Female Hemodynamics Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases Ligation Lung Male Papio papio Respiration, Artificial Respiratory System

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