Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.

Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G
Nat Genet. 2005 37 (10): 1072-81

PMID: 16170315 · DOI:10.1038/ng1642

Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.

MeSH Terms (17)

Alleles Animals Disease Models, Animal Gene Deletion Homeodomain Proteins Insulin Leptin Lipid Metabolism Lipids Liver Lymph Lymphatic Abnormalities Lymphatic Vessels Mice Mice, Knockout Obesity Tumor Suppressor Proteins

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