Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment.

Boutté AM, Neely MD, Bird TD, Montine KS, Montine TJ
J Alzheimers Dis. 2005 8 (1): 1-6

PMID: 16155344 · DOI:10.3233/jad-2005-8101

MeSH Terms (21)

Aged Aged, 80 and over Alzheimer Disease Brain Chromosomes, Human, Pair 17 Cognition Disorders Dementia DNA Mutational Analysis Female Genetic Linkage Humans Male Membrane Proteins Microtubule-Associated Proteins Microtubules Paclitaxel Parkinsonian Disorders Presenilin-2 tau Proteins Tubulin Tubulin Modulators

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