A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.

Rodriguez AL, Nong Y, Sekaran NK, Alagille D, Tamagnan GD, Conn PJ
Mol Pharmacol. 2005 68 (6): 1793-802

PMID: 16155210 · DOI:10.1124/mol.105.016139

MeSH Terms (19)

Alkynes Allosteric Regulation Allosteric Site Animals Brain Cell Line, Tumor Drug Interactions Electrophysiology Glutamic Acid Humans Ligands Neurons Pyridines Radioligand Assay Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Transfection

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