Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.

Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI
Genesis. 2005 43 (2): 80-6

PMID: 16108006 · DOI:10.1002/gene.20157

We generated transgenic mice expressing firefly (Photinus pyralis) luciferase (luc) under the control of the mouse insulin I promoter (MIP). The mice have normal glucose tolerance and pancreatic islet architecture. The luciferase-expressing beta cells can be readily visualized in living mice using whole-body bioluminescent imaging. The MIP-luc transgenic mice may be useful for monitoring changes in beta cell function or mass in living animals with normal or altered metabolic states.

genesis 43:80-86, 2005. (c) 2005 Wiley-Liss, Inc.

MeSH Terms (10)

Animals Cell Culture Techniques Insulin-Secreting Cells Luciferases, Firefly Luminescent Agents Mice Mice, Transgenic Proinsulin Promoter Regions, Genetic Transgenes

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