The impact of a normoglycemic management protocol on clinical outcomes in the trauma intensive care unit.

Collier B, Diaz J, Forbes R, Morris J, May A, Guy J, Ozdas A, Dupont W, Miller R, Jensen G
JPEN J Parenter Enteral Nutr. 2005 29 (5): 353-8; discussion 359

PMID: 16107598 · DOI:10.1177/0148607105029005353

BACKGROUND - The purpose of this study was to determine if protocol-driven normoglycemic management in trauma patients affected glucose control, ventilator-associated pneumonia, surgical-site infection, and inpatient mortality.

METHODS - A prospective, consecutive-series, historically controlled study design evaluated protocol-driven normoglycemic management among trauma patients at Vanderbilt University Medical Center. Those mechanically ventilated > or =24 hours and > or =15 years of age were included. A glycemic-control protocol required insulin infusion therapy for glucose >110 mg/dL. Control patients included those who met criteria, were admitted the year preceding protocol implementation, and had hyperglycemia treated at the physician's discretion.

RESULTS - Eight hundred eighteen patients met study criteria; 383 were managed without protocol; 435 underwent protocol. The protocol group had lower glucose levels 7 of 14 days measured. After admission, both groups had mean daily glucose levels <150 mg/dL. No difference in pneumonia (31.6% vs 34.5%; p = .413), surgical infection (5.0% vs 5.7%; p = .645) or mortality (12.3% vs 13.1%; p = .722) occurred between groups. If one episode of blood glucose level was > or =150 mg/dL (n = 638; 78.0%), outcomes were worse: higher daily glucose levels for 14 days after admission (p < .001), pneumonia rates (35.9% vs 23.3%; p = .002), and mortality (14.6% vs 6.1%; p = .002). One or more days of glucose > or =150 mg/dL had a 2- to 3-fold increase in the odds of death. Protocol use in these patients was not associated with outcome improvement.

CONCLUSIONS - Protocol-driven management decreased glucose levels 7 of 14 days after admission without outcome change. One or more glucose levels > or =150 mg/dL were associated with worse outcome.

MeSH Terms (18)

Adult Blood Glucose Clinical Protocols Critical Illness Female Hospital Mortality Humans Hyperglycemia Hypoglycemic Agents Insulin Length of Stay Male Pneumonia Prospective Studies Respiration, Artificial Surgical Wound Infection Trauma Centers Treatment Outcome

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