Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.

Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C, Cleveland JL, Tansey WP, Lowe SW
Nature. 2005 436 (7052): 807-11

PMID: 16094360 · PMCID: PMC4599579 · DOI:10.1038/nature03845

The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain their ability to stimulate proliferation and activate p53, but are defective at promoting apoptosis due to a failure to induce the BH3-only protein Bim (a member of the B cell lymphoma 2 (Bcl2) family) and effectively inhibit Bcl2. Disruption of apoptosis through enforced expression of Bcl2, or loss of either Bim or p53 function, enables wild-type MYC to produce lymphomas as efficiently as mutant MYC. These data show how parallel apoptotic pathways act together to suppress MYC-induced transformation, and how mutant MYC proteins, by selectively disabling a p53-independent pathway, enable tumour cells to evade p53 action during lymphomagenesis.

MeSH Terms (24)

Adoptive Transfer Alleles Animals Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Burkitt Lymphoma Carrier Proteins Cell Cycle Proteins Cell Proliferation Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p21 Genes, myc Humans Membrane Proteins Mice Mice, Inbred C57BL Mutation Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc Stem Cell Transplantation Tumor Suppressor Protein p14ARF Tumor Suppressor Protein p53

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