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Selective excitation of myelin water using inversion-recovery-based preparations.

Travis AR, Does MD
Magn Reson Med. 2005 54 (3): 743-7

PMID: 16088884 · DOI:10.1002/mrm.20606

T1 and T2 relaxation of excised frog sciatic nerve water was characterized at 7 T. Based on these findings, optimal timings for multiple inversion-recovery magnetization preparations were determined to selectively excite the so-called myelin-water T2 component. Subsequent double inversion-recovery and triple inversion-recovery preparations were used in combination with CPMG acquisitions to experimentally determine optimal timings and effect of the preparation. Using double inversion-recovery, optimal timings were found to excite magnetization that is predominantly (approximately 93%) derived from the myelin-water component. Greater selectivity (approximately 96%) was found by extending the preparation to triple inversion-recovery, at the price of decreasing SNR by a factor of approximately 2.

Copyright (c) 2005 Wiley-Liss, Inc.

MeSH Terms (8)

Animals Artifacts Body Water In Vitro Techniques Magnetic Resonance Imaging Myelin Sheath Sciatic Nerve Xenopus laevis

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