Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young.

Cox NJ, Xiang KS, Fajans SS, Bell GI
Diabetes. 1992 41 (4): 401-7

PMID: 1607066 · DOI:10.2337/diab.41.4.401

During our search for a marker for non-insulin-dependent diabetes mellitus (NIDDM) in a large multigenerational family with a form of NIDDM termed maturity-onset diabetes of the young (MODY), we learned a great deal that may serve to streamline the search for diabetes-susceptibility genes in other families. We describe here our experience and suggest strategies that may enhance the search for markers for other diabetes susceptibility genes with genetic linkage approaches.

MeSH Terms (10)

Chromosome Mapping Diabetes Mellitus, Type 2 Disease Susceptibility DNA Female Genes Genetic Markers Humans Male Pedigree

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