Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.

Halatchev IG, Cone RD
Cell Metab. 2005 1 (3): 159-68

PMID: 16054059 · DOI:10.1016/j.cmet.2005.02.003

Peptide YY (PYY) is a postprandially released gut hormone. Peripheral administration of one form of the peptide PYY3-36 produces a short-term reduction in food intake in rodents. Initial reports suggested that effects of PYY3-36 on food intake are mediated by increasing the anorexigenic drive from melanocortin neurons in the hypothalamic arcuate nucleus. However, more recent data have demonstrated that the anorexigenic activity of PYY3-36 is not dependent on melanocortin ligands or their receptors in the CNS. We demonstrate here that the anorexigenic actions of PYY3-36 are also not dependent on the vagus nerve, a common pathway of satiety signaling. Peripherally administered PYY3-36 activates neurons in the area postrema and nucleus tractus solitarius, brainstem areas known to mediate effects of certain aversive stimuli. Furthermore, peripheral administration of PYY3-36 causes conditioned taste aversion in mice. Thus, inhibition of food intake by PYY3-36 may result in part from induction of an aversive response.

MeSH Terms (14)

Animals Area Postrema Aversive Therapy Brain Stem Feeding Behavior Mice Mice, Inbred C57BL Mice, Transgenic Neurons Peptide Fragments Peptide YY Solitary Nucleus Taste Vagus Nerve

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