Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.

Merritt WK, Nechev LV, Scholdberg TA, Dean SM, Kiehna SE, Chang JC, Harris TM, Harris CM, Lloyd RS, Stone MP
Biochemistry. 2005 44 (30): 10081-92

PMID: 16042385 · PMCID: PMC2585418 · DOI:10.1021/bi047263g

MeSH Terms (16)

Alkylating Agents Base Pairing Butadienes Butylene Glycols Codon Cross-Linking Reagents Deoxyadenosines DNA Adducts Epoxy Compounds Genes, ras Humans Mutagens Nuclear Magnetic Resonance, Biomolecular Nucleic Acid Heteroduplexes Oligodeoxyribonucleotides Protons

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