Polyclonal antibody-induced serum sickness in renal transplant recipients: treatment with therapeutic plasma exchange.

Tanriover B, Chuang P, Fishbach B, Helderman JH, Kizilisik T, Nylander W, Shaffer D, Langone AJ
Transplantation. 2005 80 (2): 279-81

PMID: 16041276 · DOI:10.1097/01.tp.0000165093.13046.b3

Serum sickness is an immune-complex mediated illness that frequently occurs in patients after polyclonal antibody therapy (ATGAM or thymoglobulin). Serum sickness presents with significant morbidity but is self-limited and resolves with prolonged steroid therapy. We present five renal transplant patients who developed serum sickness after polyclonal antibody treatment with severe symptoms that persisted after being started on systemic steroids. These patients underwent one or two courses of therapeutic plasma exchange (TPE) with subsequent complete resolution of their symptoms. Renal transplant recipients with serum sickness after polyclonal antibody therapy may benefit from TPE by accelerating their time to recovery and thereby reducing overall morbidity.

MeSH Terms (15)

Adult Animals Antilymphocyte Serum Female Horses Humans Immunosuppressive Agents Kidney Transplantation Male Mice Middle Aged Plasma Exchange Rabbits Serum Sickness Tissue Donors

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