Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.

Bianchini EP, Orcutt SJ, Panizzi P, Bock PE, Krishnaswamy S
Proc Natl Acad Sci U S A. 2005 102 (29): 10099-104

PMID: 16006504 · PMCID: PMC1174926 · DOI:10.1073/pnas.0504704102

MeSH Terms (15)

Binding Sites Enzyme Activation Enzyme Precursors Fluorescence Humans Kinetics Models, Molecular Mutation Nitracrine Protein Conformation Prothrombin Structure-Activity Relationship Substrate Specificity Thrombin Thromboplastin

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