Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes.

Weitkamp JH, Lafleur BJ, Greenberg HB, Crowe JE
Hum Immunol. 2005 66 (6): 666-76

PMID: 15993712 · DOI:10.1016/j.humimm.2005.02.008

MeSH Terms (15)

Adult Amino Acid Motifs Antibodies, Viral B-Lymphocytes Base Pairing Clone Cells Evolution, Molecular Humans Immunoglobulin Heavy Chains Immunoglobulin Variable Region Infant RNA, Messenger Rotavirus Rotavirus Infections Somatic Hypermutation, Immunoglobulin

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