Novel strategies for the early detection and prevention of lung cancer.

Wardwell NR, Massion PP
Semin Oncol. 2005 32 (3): 259-68

PMID: 15988680

Lung cancer is the leading cause of cancer death in the United States. Despite evidence of molecular abnormalities in biological specimens, progress in this disease is hampered by the lack of diagnostic markers useful for clinical practice. The majority of patients with lung cancer are still diagnosed at an advanced stage, when prognosis is poor. This article reviews new strategies being studied for the early detection of lung cancer. These strategies involve new methods of imaging (including low-dose computed tomography [CT] scanning), DNA analysis, and proteomic-based techniques. These strategies have not only improved our understanding of lung cancer but show promise in offering better survival to patients with this deadly disease. Of paramount importance in the search for methods of early detection is the need for the identification of the ideal population to screen, a multidisciplinary approach, and validation of promising techniques.

MeSH Terms (10)

Anticarcinogenic Agents Biomarkers, Tumor Bronchoscopy Gene Expression Profiling Genomic Instability Humans Lung Neoplasms Positron-Emission Tomography Proteomics Tomography, Spiral Computed

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