Role of nuclear factor-kappa B in melanoma.

Amiri KI, Richmond A
Cancer Metastasis Rev. 2005 24 (2): 301-13

PMID: 15986139 · PMCID: PMC2668255 · DOI:10.1007/s10555-005-1579-7

Nuclear Factor-kappa B (NF-kappa B) is an inducible transcription factor that regulates the expression of many genes involved in the immune response. Recently, NF-kappa B activity has been shown to be upregulated in many cancers, including melanoma. Data indicate that the enhanced activation of NF-kappa B may be due to deregulations in upstream signaling pathways such as Ras/Raf, PI3K/Akt, and NIK. Multiple studies have shown that NF-kappa B is involved in the regulation of apoptosis, angiogenesis, and tumor cell invasion, all of which indicate the important role of NF-kappa B in tumorigenesis. Thus, understanding the molecular mechanism of melanoma progression will aid in designing new therapeutic approaches for melanoma. In this review, the association between NF-kappa B and melanoma tumorigenesis are discussed. Additionally, the potential of emerging selective NF-kappa B inhibitors for the treatment of melanoma is reviewed.

MeSH Terms (8)

Cell Transformation, Neoplastic Disease Progression Gene Expression Regulation, Neoplastic Humans Melanoma NF-kappa B Skin Neoplasms Up-Regulation

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