Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia.

Weng HR, Aravindan N, Cata JP, Chen JH, Shaw AD, Dougherty PM
Neurosci Lett. 2005 386 (1): 18-22

PMID: 15975716 · DOI:10.1016/j.neulet.2005.05.049

Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia. Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats. These changes were further confirmed using an enzyme-linked immunosorbent assay that confirmed downregulation of GLAST by 36% (P<0.05) and GLT-1 by 18% (P<0.05) in the L4-L5 spinal cord of taxol-treated rats. These data indicate that downregulation of glutamate transporters may contribute to the development of hyperalgesia induced by taxol and suggest that glutamate transporters may be a new target for treatment of pain.

MeSH Terms (22)

Amino Acid Transport System X-AG Animals Antineoplastic Agents, Phytogenic Cell Communication Disease Models, Animal Down-Regulation Excitatory Amino Acid Transporter 1 Excitatory Amino Acid Transporter 2 Glutamate Plasma Membrane Transport Proteins Glutamic Acid Hyperalgesia Male Neuroglia Nociceptors Paclitaxel Peripheral Nervous System Diseases Posterior Horn Cells Presynaptic Terminals Rats Rats, Sprague-Dawley Symporters Synaptic Transmission

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