Interaction effects between estrogen receptor alpha and vitamin D receptor genes on age at menarche in Chinese women.

Xu H, Long JR, Li MX, Deng HW
Acta Pharmacol Sin. 2005 26 (7): 860-4

PMID: 15960894 · DOI:10.1111/j.1745-7254.2005.00122.x

AIM - To evaluate whether estrogen receptor alpha (ER-alpha) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women.

METHODS - A total of 390 pre-menopausal Chinese women were genotyped at the ER-alpha PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).

RESULTS - Neither the ER-alpha gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-alpha gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01).

CONCLUSION - We found that neither the ER-alpha gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women.

MeSH Terms (13)

Adult Age Factors Asian Continental Ancestry Group China Estrogen Receptor alpha Female Gene Frequency Genotype Humans Menarche Polymorphism, Restriction Fragment Length Premenopause Receptors, Calcitriol

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