Clinical and immunogenetic correlates of abacavir hypersensitivity.

Phillips EJ, Wong GA, Kaul R, Shahabi K, Nolan DA, Knowles SR, Martin AM, Mallal SA, Shear NH
AIDS. 2005 19 (9): 979-81

PMID: 15905681 · DOI:10.1097/01.aids.0000171414.99409.fb

A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CD8 proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

MeSH Terms (9)

Anti-HIV Agents CD8-Positive T-Lymphocytes Dideoxynucleosides Drug Eruptions Genetic Predisposition to Disease HLA-B Antigens Humans Patch Tests Reverse Transcriptase Inhibitors

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