Evi-1 expression in Xenopus.

Mead PE, Parganas E, Ohtsuka S, Morishita K, Gamer L, Kuliyev E, Wright CV, Ihle JN
Gene Expr Patterns. 2005 5 (5): 601-8

PMID: 15905132 · DOI:10.1016/j.modgep.2005.03.007

The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck.

MeSH Terms (23)

Amino Acid Sequence Animals Blotting, Northern Brain Cloning, Molecular DNA, Complementary DNA-Binding Proteins Gene Expression Regulation, Developmental Gene Library In Situ Hybridization Kidney MDS1 and EVI1 Complex Locus Protein Mice Molecular Sequence Data Neural Crest Oocytes Poly A Proto-Oncogenes Sequence Homology, Amino Acid Time Factors Transcription, Genetic Transcription Factors Xenopus laevis

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