An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH
Nature. 2005 435 (7042): 677-81

PMID: 15902208 · DOI:10.1038/nature03579

MeSH Terms (23)

Animals Antineoplastic Agents Apoptosis Biphenyl Compounds Carcinoma, Small Cell Cell Line, Tumor Cytochromes c Disease Models, Animal Drug Synergism Humans Lymphoma Magnetic Resonance Spectroscopy Mice Mitochondria Models, Molecular Neoplasms Nitrophenols Paclitaxel Piperazines Proto-Oncogene Proteins c-bcl-2 Structure-Activity Relationship Sulfonamides Survival Rate

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