Helicobacter pylori and gastroduodenal disease.

Cover TL, Blaser MJ
Annu Rev Med. 1992 43: 135-45

PMID: 1580578 · DOI:10.1146/annurev.me.43.020192.001031

Helicobacter pylori infection is now recognized as the primary cause of active chronic gastritis in humans. Most infected persons remain asymptomatic, but are at increased risk for the development of peptic ulcer disease and possibly gastric cancer. The pathogenesis of this infection is not well understood, but motility and urease activity are virulence factors in an animal model. The eradication of H. pylori infection is associated with resolution of gastritis and a decreased rate of duodenal ulcer recurrence.

MeSH Terms (8)

Bacteriological Techniques Duodenitis Gastritis Helicobacter Infections Helicobacter pylori Humans Peptic Ulcer Virulence

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