Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

Jacobson PB, von Geldern TW, Ohman L, Osterland M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Marsh K, Beno DW, Nga-Nguyen B, Kym PR, Link JT, Tu N, Edgerton DS, Cherrington A, Efendic S, Lane BC, Opgenorth TJ
J Pharmacol Exp Ther. 2005 314 (1): 191-200

PMID: 15784656 · DOI:10.1124/jpet.104.081257

MeSH Terms (27)

3T3 Cells Adipocytes Animals Biotransformation Blood Glucose Cell Differentiation Cholic Acids Diabetes Mellitus, Type 2 Dogs Drug Synergism Estrone Glucocorticoids Glucose Glutamate-Ammonia Ligase Hypoglycemic Agents Liver Male Mice Obesity Prednisolone Rats Rats, Zucker Receptors, Glucocorticoid Reverse Transcriptase Polymerase Chain Reaction Rosiglitazone Thiazolidinediones Tyrosine Transaminase

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