Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.

Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS
Cell. 2005 120 (5): 701-13

PMID: 15766532 · DOI:10.1016/j.cell.2005.01.015

Cerebral deposition of beta-amyloid (Abeta) peptides is an invariant pathological hallmark in brains of patients with Alzheimer's disease (AD) and transgenic mice coexpressing familial AD-linked APP and PS1 variants. We now report that exposure of transgenic mice to an "enriched environment" results in pronounced reductions in cerebral Abeta levels and amyloid deposits, compared to animals raised under "standard housing" conditions. The enzymatic activity of an Abeta-degrading endopeptidase, neprilysin, is elevated in the brains of "enriched" mice and inversely correlated with amyloid burden. Moreover, DNA microarray analysis revealed selective upregulation in levels of transcripts encoded by genes associated with learning and memory, vasculogenesis, neurogenesis, cell survival pathways, Abeta sequestration, and prostaglandin synthesis. These studies provide evidence that environmental enrichment leads to reductions in steady-state levels of cerebral Abeta peptides and amyloid deposition and selective upregulation in levels of specific transcripts in brains of transgenic mice.

MeSH Terms (20)

Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Cerebral Cortex Disease Models, Animal Down-Regulation Environment Exploratory Behavior Gene Expression Regulation Male Membrane Proteins Mice Mice, Transgenic Neprilysin Nerve Tissue Proteins Oligonucleotide Array Sequence Analysis Plaque, Amyloid Presenilin-1 Up-Regulation

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