Helicobacter pylori VacA, a paradigm for toxin multifunctionality.

Cover TL, Blanke SR
Nat Rev Microbiol. 2005 3 (4): 320-32

PMID: 15759043 · DOI:10.1038/nrmicro1095

Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to successfully colonize their hosts. In recent years, there has been increased recognition that many bacterial toxins are multifunctional proteins that can have pleiotropic effects on mammalian cells and tissues. In this review, we examine a multifunctional toxin (VacA) that is produced by the bacterium Helicobacter pylori. The actions of H. pylori VacA represent a paradigm for how bacterial secreted toxins contribute to colonization and virulence in multiple ways.

MeSH Terms (14)

Animals Antigen Presentation Bacterial Proteins Bacterial Toxins Epithelial Cells Gastric Mucosa Helicobacter Infections Helicobacter pylori Humans Peptic Ulcer Phagocytosis Stomach Neoplasms T-Lymphocytes Virulence

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